T-cell Acute Lymphoblastic Leukemia (T-ALL) is an aggressive form of leukemia. While T-ALL can affect people of all ages, it’s more common in children.

T-ALL is currently treated with aggressive chemotherapy and radiation, which can be difficult for people (especially children) to tolerate. Even with aggressive treatment and maximum doses of chemotherapy and radiation, many patients continue to worsen (a term called refractory disease) or relapse within 5 years. A need exists for more effective and tolerable treatments for T-ALL.